Periodical (Journal)

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ISSN  :   1752-8054 ( Print )   |   1752-8062 ( Online )   Active

Journal Clinical and Translational Science (CTS)

Aim & Scope

Clinical and Translational Science (CTS), an official journal of the American Society for Clinical Pharmacology and Therapeutics, highlights original translational medicine research that helps bridge laboratory discoveries with the diagnosis and treatment of human disease. Translational medicine is a multi-faceted discipline with a focus on translational therapeutics. In a broad sense, translational medicine bridges across the discovery, development, regulation, and utilization spectrum. Research may appear as Full Articles, Brief Reports, Commentaries, Phase Forwards (clinical trials), Reviews, or Tutorials. CTS also includes invited didactic content that covers the connections between clinical pharmacology and translational medicine. These additional features provide context for research articles and facilitate understanding for a wide array of individuals interested in clinical and translational science. CTS welcomes high quality, scientifically sound, original manuscripts focused on clinical pharmacology and translational science, including animal, in vitro, in silico, and clinical studies supporting the breadth of drug discovery, development, regulation and clinical use of both traditional drugs and innovative modalities. [1]

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2024 - VOLUME 17, ISSUE 7
27 RESULTS in 16 msec
2024-07-01

PBPK‐led assessment of antimalarial drugs as candidates for Covid‐19: Simulating concentrations at the site of action to inform repurposing strategies

N Abla , L Almond , J Bonner , ... , J Möhrle

Clinical and Translational Science (CTS) , 2024 - VOLUME 17, ISSUE 7

10.1111/cts.13865

0 43

2024-07-01

Pharmacokinetic drug–drug interactions of JBPOS0101 mediated by cytochrome P450 3A4 and UDP‐glucuronosyltransferases

S Hwang , Y Choi , M Kim , S Lee

Clinical and Translational Science (CTS) , 2024 - VOLUME 17, ISSUE 7

10.1111/cts.13892

0 21

2024-07-01

Issue Information

No authors listed.

Clinical and Translational Science (CTS) , 2024 - VOLUME 17, ISSUE 7

10.1111/cts.13338

0 0

2024-07-01

Reduced hepatic impairment study to evaluate pharmacokinetics and safety of zavegepant and to inform dosing recommendation for hepatic impairment.

R Bhardwaj , MK Donohue , J Madonia , ... , J Liu

Clinical and Translational Science (CTS) , 2024 - VOLUME 17, ISSUE 7 , p e13813.

10.1111/cts.13813

  0 26

2024-07-00

Dalzanemdor (SAGE‐718), a novel, investigational N‐methyl‐D‐aspartate receptor positive allosteric modulator: Safety, tolerability, and clinical pharmacology in randomized dose‐finding studies in healthy participants and an open‐label study in participants with Huntington's disease

A Koenig , M Lewis , J Wald , ... , M Quirk

Clinical and Translational Science (CTS) , 2024 - VOLUME 17, ISSUE 7 , p e13852.

10.1111/cts.13852

  0 35

2024-07-01

A phase I randomized study to evaluate safety, pharmacokinetics, and pharmacodynamics of SIR2446M, a selective RIPK1 inhibitor, in healthy participants.

ALA Sun , JD Gillies , Y Shen , ... , L Song

Clinical and Translational Science (CTS) , 2024 - VOLUME 17, ISSUE 7 , p e13857.

10.1111/cts.13857

  0 23

2024-07-01

Strategies for developing 3D printed ovarian model for restoring fertility.

R Nair , M Kasturi , V Mathur , ... , K S Vasanthan

Clinical and Translational Science (CTS) , 2024 - VOLUME 17, ISSUE 7 , p e13863.

10.1111/cts.13863

  Review
0 91

2024-07-01

Alkylating agents-induced gonadotoxicity in prepubertal males: Insights on the clinical and preclinical front.

S Sriram , T Macedo , A Mavinkurve-Groothuis , ... , LHJ Looijenga

Clinical and Translational Science (CTS) , 2024 - VOLUME 17, ISSUE 7 , p e13866.

10.1111/cts.13866

  Review
0 161

2024-07-01

Age-related off-label drug prescribing in pediatric patients in South Korea and consistency of labeling compared to the United States, Europe, and Japan.

B Park , H Lee , H Choi , J Lee

Clinical and Translational Science (CTS) , 2024 - VOLUME 17, ISSUE 7 , p e13869.

10.1111/cts.13869

  0 18

2024-07-00

Integration of individual preclinical and clinical anti-infective PKPD data to predict clinical study outcomes.

V Aranzana-Climent , W van Os , A Nutman , ... , LE Friberg

Clinical and Translational Science (CTS) , 2024 - VOLUME 17, ISSUE 7 , p e13870.

10.1111/cts.13870

  0 26

 

Editorial Retractions, Expressions of Concern and External Notices
7 RESULTS in 12 msec
2021-09-01

Pharmacokinetic, pharmacodynamic, and immunogenic rationale for optimal dosing of pegvaliase, a PEGylated bacterial enzyme, in adult patients with phenylketonuria.

Y Qi , G Patel , J Henshaw , ... , B Schweighardt

Clinical and Translational Science (CTS)
2021 - VOLUME 14, ISSUE 5 pp 1894-1905.
 
4 24
2024-07-05

PubPeer Comment

David C. Norris

PubPeer
2024 - VOLUME 2024, ISSUE 7

  Website - Forum Post External CQC
0 0
2022-02-01

MicroRNA-100 Enhances Autophagy and Suppresses Migration and Invasion of Renal Cell Carcinoma Cells via Disruption of NOX4-Dependent mTOR Pathway.

X Liu , L Zhong , P Li , P Zhao

Clinical and Translational Science (CTS)
2022 - VOLUME 15, ISSUE 2 pp 567-575.
 
14 44
2022-01-18

Expression of Concern

No authors listed.

Clinical and Translational Science (CTS)
2022 - VOLUME 15, ISSUE 2

p 576.
  Expression of Concern
0 1
2022-03-16

PubPeer Comment

Hoya Camphorifolia

PubPeer
2022 - VOLUME 2022, ISSUE 3

  Website - Forum Post External CQC
0 0
2021-09-01

Retracted: Silencing of Exosomal miR-296-5p Derived from Endothelial Progenitor Cells Enhances Thrombolysis and Recanalization in Deep Vein Thrombosis.

J Wang , Z Yang , S Liu , ... , Y Zhao

Clinical and Translational Science (CTS)
2021 - VOLUME 14, ISSUE 5 pp 2065-2074.
  Retracted Publication
1 0
2022-05-03

Notice of Retraction

No authors listed.

Clinical and Translational Science (CTS)
2022 - VOLUME 15, ISSUE 2

p 577.
  Retraction of Publication
0 1
2021-03-10

PubPeer Comment

Gaultheria Insana

PubPeer
2021 - VOLUME 2021, ISSUE 3

  Website - Forum Post External CQC
0 0
2021-09-01

Retracted: MicroRNA let-7b Inhibits Proliferation and Induces Apoptosis of Castration-Resistant Prostate Cancer Cells by Blocking the Ras/Rho Signaling Pathway via NRAS.

L Huang , L Wang , L Wang , ... , S Wang

Clinical and Translational Science (CTS)
2021 - VOLUME 14, ISSUE 5 pp 2055-2064.
  Retracted Publication
5 1
2022-05-03

Notice of Retraction

No authors listed.

Clinical and Translational Science (CTS)
2022 - VOLUME 15, ISSUE 2

p 578.
  Retraction of Publication
0 1
2021-08-27

PubPeer Comment

Hoya Camphorifolia

PubPeer
2021 - VOLUME 2021, ISSUE 8

  Website - Forum Post External CQC
0 0
2021-09-01

Hydrazinocurcumin Induces Apoptosis of Hepatocellular Carcinoma Cells Through the p38 MAPK Pathway.

H He , K Qiao , C Wang , ... , L Peng

Clinical and Translational Science (CTS)
2021 - VOLUME 14, ISSUE 5 pp 2075-2084.
 
5 32
2021-07-29

Expression of Concern

No authors listed.

Clinical and Translational Science (CTS)
2021 - VOLUME 14, ISSUE 5

p 2086.
  Expression of Concern
0 1
2021-09-13

PubPeer Comment

Hoya Camphorifolia

PubPeer
2021 - VOLUME 2021, ISSUE 9

  Website - Forum Post External CQC
0 0
2019-03-01

Tranilast Treatment Attenuates Cerebral Ischemia-Reperfusion Injury in Rats Through the Inhibition of Inflammatory Responses Mediated by NF-κB and PPARs.

Y Zhuo , J Zhuo

Clinical and Translational Science (CTS)
2019 - VOLUME 12, ISSUE 2 pp 196-202.
 
10 26
2021-07-29

Expression of Concern

No authors listed.

Clinical and Translational Science (CTS)
2021 - VOLUME 14, ISSUE 5

p 2085.
  Expression of Concern
0 1
2008-09-01

ErbB2 induces Notch1 activity and function in breast cancer cells.

J Lindsay , X Jiao , T Sakamaki , ... , RG Pestell

Clinical and Translational Science (CTS)
2008 - VOLUME 1, ISSUE 2 pp 107-115.
 
27 41
2015-03-20

PubPeer Comment

Peer 1

PubPeer
2015 - VOLUME 2015, ISSUE 3

  Website - Forum Post External CQC
0 0