Aim & Scope
Disease Models & Mechanisms (DMM) publishes original research, resources and invited reviews that focus on the use of model systems to better understand, diagnose and treat human disease. The primary aim of DMM is to promote human health by inspiring collaboration between basic and clinical researchers in translational science. The journal is committed to presenting highly significant research that meets this goal. The interdisciplinary nature of DMM means that a diverse range of diseases, approaches and models fall within its scope. Examples of DMM content: Basic research that significantly advances our understanding of human disease mechanisms, diagnosis or treatment, and is of broad relevance; Drug screens and preclinical analyses of candidate therapies using model systems; Presentation of new models that have been thoroughly validated to demonstrate their utility in disease studies; New methods and resources that provide broadly useful tools for a disease and/or model community; Comprehensive, expert reviews and posters addressing current and emerging themes in biomedical science; Interviews with leading scientists in translational research; Editorials that discuss wider issues of interest to the community, including regulatory, ethical and policy issues; Special collections that collate articles relating to a particular disease area or model system. Model systems of interest include: Vertebrates such as mice, zebrafish, frogs, rats and other mammals; Invertebrates such as Drosophila melanogaster and Caenorhabditis elegans; Unique in vitro or ex vivo models, such as stem-cell-based models, organoids and systems based on patient material; Microorganisms such as yeast and Dictyostelium; Other biological systems with relevance to human disease research. Disease areas of interest include: Cancer; Neurodegenerative and neurological diseases; Psychiatric disorders; Metabolic disorders, including diabetes and obesity; Cardiovascular diseases, stroke and hypertension; Gastrointestinal diseases; Infectious diseases; Autoimmunity and inflammation; Developmental diseases; Musculoskeletal disorders; Renal or liver disease; Eye disorders; Drug and biomarker discovery/screening; Stem cells therapies in regenerative medicine. [1]
2024
Functional distinction in oncogenic Ras variant activity in Caenorhabditis elegans.
Disease Models and Mechanisms , 2024
0
0
Editorial Retractions, Expressions of Concern and External Notices
AI Khan , SM Coldewey , NS Patel , ... , C Thiemermann
Disease Models and Mechanisms2013 - VOLUME 6, ISSUE 4 pp 1021-1030.
36 61
KK Nandra , M Collino , M Rogazzo , ... , C Thiemermann
Disease Models and Mechanisms2013 - VOLUME 6, ISSUE 3 pp 701-709.
17 54
Inhibition of IκB kinase reduces the multiple organ dysfunction caused by sepsis in the mouse.
SM Coldewey , M Rogazzo , M Collino , ... , C Thiemermann
Disease Models and Mechanisms2013 - VOLUME 6, ISSUE 4 pp 1031-1042.
46 57
Medaka as a model for human nonalcoholic steatohepatitis.
T Matsumoto , S Terai , T Oishi , ... , I Sakaida
Disease Models and Mechanisms2010 - VOLUME 3, ISSUES 7-8 pp 431-440.
32 31
Leptin induces muscle wasting in a zebrafish kras-driven hepatocellular carcinoma (HCC) model.
Q Yang , C Yan , X Wang , Z Gong
Disease Models and Mechanisms2019 - VOLUME 12, ISSUE 2 p dmm038240.
19 57
Á González-Rodríguez , B Reibert , T Amann , ... , ÁM Valverde
Disease Models and Mechanisms2014 - VOLUME 7, ISSUE 9 pp 1093-1100.
14 44
Molecular characterization of hepatocarcinogenesis using mouse models.
WW Teoh , M Xie , A Vijayaraghavan , ... , K Sabapathy
Disease Models and Mechanisms2015 - VOLUME 8, ISSUE 7 pp 743-753.
6 24
A necrotic stimulus is required to maximize matrix-mediated myogenesis in mice.
D Kuraitis , MG Berardinelli , EJ Suuronen , A Musarò
Disease Models and Mechanisms2013 - VOLUME 6, ISSUE 3 pp 793-801.
5 42
Y Zhang , T Poobalasingam , LL Yates , ... , CH Dean
Disease Models and Mechanisms2018 - VOLUME 11, ISSUE 1 p dmm031369.
8 38
Vascular regression precedes motor neuron loss in the FUS (1-359) ALS mouse model.
M Crivello , MC Hogg , E Jirström , ... , JHM Prehn
Disease Models and Mechanisms2019 - VOLUME 12, ISSUE 8 p dmm040238.
11 51